Global phenylethyl resorcinol market 2017 industry research. Sfda consults on approval of phenylethyl resorcinol as a. It is a colourless liquid that is slightly soluble in water 2 ml100 ml h 2 o, but miscible with most organic solvents. Phenylethyl resorcinol pr is a synthetic compound that it has anti tyrosinase property, which tyrosinase is an enzyme substrate for melanin production. A skinlightening and antioxidant active ingredient derived from a molecule that exists naturally in pine tree. Very little information was found on symwhite 377 or phenylethyl resorcinol that wasnt published by symrise. Though the results from the manufacturer sound quite promising, a skinlightening study from 20 involving phenylethyl resorcinol shows quite moderate results. Pdf ethosomes of phenylethyl resorcinol as vesicular. On 7 august, 2012, sfda started to seek comments on approval of phenylethyl resorcinol as a cosmetic ingredient. Pdf fabrication of carboxylmethyl chitosan nanocarrier. Hexylresorcinol is a synthetic ingredient that has been shown to have skinbrightening ability but there is very limited research about it on skin.
About the skin deep ratings ewg provides information on personal care product ingredients from the published scientific literature, to supplement incomplete data available from companies and the government. May cause skin sensitization, an allergic reaction, which becomes evident upon reexposure to this material. Phenylethyl resorcinol is a highly efficient safe skin lightener. May cause severe gastrointestinal tract irritation with nausea, vomiting and possible burns. Resorcinol 1 foreword concise international chemical assessment documents cicads are published by the international programme on chemical safety ipcs a cooperative programme of the world health organization who, the international labour organization ilo, and the united nations environment programme unep.
This msds has been prepared according to the hazard criteria of the controlled products. Phenylethyl alcohol definition of phenylethyl alcohol by. Ethosomes, transfersomes, invasomes, topical administration. Click on the desired brand to find out the drug price or cost of the drug. Phenylethyl resorcinol pr is a phenolic compound produced from resorcinol. See phenylethyl resorcinol back to ingredient dictionary. Phenylethyl resorcinol is also known as symwhite 377 and was developed by symrise researchers to serve as a lightening and brightening ingredient in skin care products, hair lightening products, and cosmetics. Find patient medical information for phenylethyl alcohol bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. China sfda is also working hard on compling a new inventory of existing cosmetic ingredient in china iecic to. Please login to display the rating of all cosmetics. Easily combine multiple files into one pdf document. Tyrosine is the substrate of tyrosinase and oxidized to ldopa in melanin synthesis.
Sfda consults on approval of phenylethyl resorcinol as a new. The results show that vivinol is significantly more effective at inhibiting tyrosinase production than both kojic acid and phenylethyl resorcinol. How to merge pdfs and combine pdf files adobe acrobat dc. Phenylethyl resorcinol in niosomes for cosmetic formulation. It is an antioxidant that is considered effective in influencing the formation of pigmentation, and therefore able to lighten the skin. Proven skin brightening efficacy, reduction of appearance of dark hair and evening of skin tone are the main functions of symwhite plus. Therefore, the primary objective of this study was to perform a comprehensive characterization of pr. It does not reveal its actual effects and skin compatibility. Global phenylethyl resorcinol market research report 2017.
The selective inhibitory effects of phenethyl alcohol on gramnegative bacteria were confirmed with a variety of species. Phenethyl alcohol, or 2phenylethanol, is the organic compound that consists of a phenethyl group c 6 h 5 ch 2 ch 2 group attached to oh. Preparation of phenylethyl resorcinol niosomes for. Show this safety data sheet to the doctor in attendance. It is a colorless liquid with a rose and honey scent and a raspberrylike taste. May be absorbed through the skin in harmful amounts. Global phenylethyl resorcinol market 2017 industry. Use of the information, documents and data from the echa website is subject to the terms and conditions of this legal notice, and subject to other binding limitations provided for under applicable law, the information, documents and data made available on the echa website may be reproduced, distributed andor used, totally or in part, for noncommercial purposes provided that echa is. Characterization and topical delivery of phenylethyl resorcinol. The other two ingredients nivitol and pmlysine were approved in march this year. All results were converted into relative units of measurement for tyrosinase inhibition efficacy figure 3. We are globally recognized as a leading provider of fragrances, flavors and active ingredients as well as aroma chemicals for the perfume, cosmetic, pharmaceutical, food and beverage industries. Resorcinol 108463 5000 u201 no chemical weapons convention. The deadline for this consultation is 31 august, 2012.
The synthesis of two new derivatives of resorcinol and a discussion of their relation to other resorcinol derivatives of therapeutic importance gardner mills albro university of massachusetts amherst follow this and additional works at. They exhibited the physical appearance in terms of particle sizes such that all formulations were in the range of 240. Table of contents global phenylethyl resorcinol market research report 2017 1 phenylethyl resorcinol market overview 1. Phenylethyl resorcinol itself can be found in inci2010 and the registrant should be symrise. Considered as an obstacle in the quest for beauty, more and more women faced with this disorder are consulting their dermatologist. Phenylethyl resorcinol ingredient for cosmetics formulations find latest products launched and their applications in relevant industry news and technical articles. It is produced by sulfonating benzene with fuming sulfuric acid and fusing the resulting benzenedisulfonic acid with caustic soda. Phenylethyl resorcinol pr has been used widely in the personal care industry as a novel skin lightening ingredient. Phenylethyl acetate, 11phenylethyl acetate, alphamethyl benzene methanol acetate. Ethosome formulations containing phenylethyl resorcinol pr were developed. The product was applied over a period of 3 months by 20 women, all of whom also used sunscreen. Albro, gardner mills, the synthesis of two new derivatives of resorcinol and a discussion of their relation to other resorcinol derivatives of therapeutic importance 1930. Selective and reversible inhibition of the synthesis of bacterial deoxyribonucleic acid by phenethyl alcohol.
Relevant data showed that samples were kept stable for at least 90 days. Section 1 chemical product and company identification. Top quality phenylethyl resorcinol items standards results appearance white to light brown powder complies purityhplc. China sfda is also working hard on compling a new inventory of existing cosmetic ingredient in china iecic to replace the old version issued in 2003. Generic drug phenylethyl resorcinol available with manufacturer details. Quizlet flashcards, activities and games help you improve your grades. The list of cosmetic products below is a selection of the most requested cosmetics that contain the ingredient phenylethyl resorcinol. It was recently stated that no additional phases can be found under atmospheric conditions druzbicki, k. Symwhite 377 phenyl ethyl resorcinol kingyoung bio technical.
Alcohols are classified as primary, secondary, or tertiary according to whether the carbon atom to which the oh group is attached is bonded to one, two, or three other. It was characterized by a vesicular size of 389 nm, low polydispersity index of 0. In the antityrosinase assay, pr performed higher effective than kojic acid. Cirs has summarized a few questions in order that symrise regulatory affairs experts might share its experience. The synthesis of two new derivatives of resorcinol and a. For breathing difficulties, oxygen may be necessary. Preparation and evaluation of phenylethyl resorcinol liposome. Alcohols are classified as primary, secondary, or tertiary according to whether the carbon atom to which the oh group is attached is bonded to one, two, or three other carbon atoms and as monohydric, dihydric, or trihydric according. Powerful antioxidant activity helps to reduce the inflammatory response and melanocyte stimulation. The improvement of skin whitening of phenylethyl resorcinol by. Phenylethyl resorcinol manufacturers, factory, suppliers from china, in case you are intrigued in almost any of our merchandise, remember to will not hesitate to make contact with us and take the initial step to create up a prosperous enterprise romance.
Enhanced stability of phenylethyl resorcinol in elastic vesicular. Phenylethyl resorcinol skincare ingredient loreal paris. Preparation of phenylethyl resorcinol niosomes for cosmetic. We provide custom synthesis and contract manufacturing from milligrams to metric tonnes. Sigmaaldrich offers a number of phenylethyl alcohol products. The phenylethyl resorcinol loaded nanostructured lipid carrier prnlc was. Phenethyl acetate is the ester resulting from the condensation of acetic acid and phenethyl alcohol.
It occurs widely in nature, being found in a variety of essential oils. Phenylethyl resorcinol alternative names no information available origin chemisch definition no information available inci function antioxidant the inci function describes solely the purpose of a cosmetic ingredient. Phenylethyl resorcinol liposome for cosmetic application was developed to enhance the water solubility and physicol stability. Contact of the eye with resorcinol has caused necrosis and corneal perforation. Development of a nanostructured lipid carrier formulation for. Request pdf characterization and topical delivery of phenylethyl resorcinol objective. Pea, 2phenylethanol, 2phenylethyl alcohol, benzyl carbinol, pea cas number.
At the end of the study, it was determined that the womens uneveness decreased by 43%. Fabrication of carboxylmethyl chitosan nanocarrier via selfassembly for efficient delivery of phenylethyl resorcinol in b16 cells article pdf available in polymers 122. Predicted data is generated using the us environmental protection agencys episuite. Like many esters, it is found in a range of fruits and biological products. If absorbed, may cause symptoms similar to those for ingestion. Synthetic antioxidant often seen in skinbrightening products. Resorcinol disulfonic acid, ho 2 c 6 h 2 hso 3 2, is a deliquescent mass obtained by the action of sulfuric acid on resorcin. Firstaid measures if breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing.
According to the clinical results of the manufacturer, 0. Request pdf development of a nanostructured lipid carrier formulation for. Explore phenylethyl resorcinol, also known as symwhite. Ethosomes of phenylethyl resorcinol as vesicular delivery. Phenylethyl resorcinol phenylethyl resorcinol is classified as. Resorcinol is also a common scaffold that is found in a class of anticancer agents, some of which luminespib, ganetespib, kw2478, and onalespib were in clinical trials. Phenylethyl resorcinol skin deep cosmetics database ewg. Symwhite plus is a blend of symwhite 377, bisabolol and pentylene glycol, stabilized in neutral oil. If inhaled if breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing.
Phenylethyl resorcinol, the chinese authority was concerned by the potential presence of resorcinol residues. Phenylethyl resorcinol manufacturers, factory, suppliers. Our pdf merger allows you to quickly combine multiple pdf files into one single pdf document, in just a few clicks. The most compelling research looked at the results of a cream with phenylethyl resorcinol plus three other skinbrightening agents. Surprisingly, there is only limited information describing the physicochemical properties of this active. Phenylethyl resorcinol can provide antioxidant protection against the oxidative stress of freeradicals. The meta 1,3 isomer is resorcinol also known as resorcin, which forms clear needle crystals used in the production of diazo dyes and plasticizers. Phenylethyl resorcinol report by material, application, and geography global forecast to 2021 is a professional and indepth research report on the worlds major regional market conditions, focusing on the main regions north america, europe and asiapacific and the main countries united states, germany, united kingdom, japan, south korea and china. However we did show that it was not a concern as described below. Pr has attracted much attention as a lightening agent in skin care products since it inhibits tyrosinase activity and thus the conversion of tyrosine to ldopa. Preparation and evaluation of phenylethyl resorcinol. Characterization and topical delivery of phenylethyl. Resorcinol has been known to cause hyperemia an excess of blood in a part, itch, dermatitis, edema, and corrosion.